Version 5.4
Homo sapiens Gene: SMARCD1
Summary
InnateDB Gene IDBG-32344.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCD1
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Synonyms BAF60A; CRACD1; Rsc6p
Species Homo sapiens
Ensembl Gene ENSG00000066117
Encoded Proteins
IDBP-29962
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-240511
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-588608
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-592451
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-601173
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-602397
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
IDBP-603558
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50084972-50100712
Strand Forward strand
Band q13.12
Transcripts
ENST00000381513 ENSP00000370924
ENST00000394963 ENSP00000378414
ENST00000551966 ENSP00000447386
ENST00000550477 ENSP00000448030
ENST00000547247
ENST00000547637
ENST00000551497 ENSP00000449825
ENST00000548573 ENSP00000448627
ENST00000549274 ENSP00000447909
ENST00000550280
ENST00000551352
ENST00000549526
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 100 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 100 [view]
Protein-Protein 100 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0032947 protein complex scaffold
Biological Process
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0048096 chromatin-mediated maintenance of transcription
Cellular Component
GO:0016514 SWI/SNF complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023018
View Gene Order
ENSBTAG00000037935
Not yet available
Pathways
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.732353 Hs.79335
RefSeq NM_003076 NM_139071
HUGO
OMIM
CCDS CCDS8797 CCDS8798
HPRD 03438
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca