Version 5.4
Homo sapiens Gene: COX14
Summary
InnateDB Gene IDBG-32425.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COX14
Gene Name cytochrome c oxidase assembly homolog 14 (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178449
Encoded Proteins
IDBP-32427
chromosome 12 open reading frame 62
IDBP-587897
chromosome 12 open reading frame 62
IDBP-595811
chromosome 12 open reading frame 62
IDBP-588122
chromosome 12 open reading frame 62
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a small single-pass transmembrane protein that localizes to mitochondria. This protein may play a role in coordinating the early steps of cytochrome c oxidase (COX; also known as complex IV) subunit assembly and, in particular, the synthesis and assembly of the COX I subunit of the holoenzyme. Mutations in this gene have been associated with mitochondrial complex IV deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50111979-50120457
Strand Forward strand
Band q13.12
Transcripts
ENST00000317943 ENSP00000326052
ENST00000550487 ENSP00000446524
ENST00000548468
ENST00000550654 ENSP00000450331
ENST00000548985 ENSP00000447776
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 4 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0033617 mitochondrial respiratory chain complex IV assembly
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023020
View Gene Order
ENSBTAG00000000808
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741707
RefSeq NM_001257133 NM_001257134 NM_032901
HUGO
OMIM
CCDS CCDS8800
HPRD 17495
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca