Version 5.4
Homo sapiens Gene: TRHR
Summary
InnateDB Gene IDBG-32510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRHR
Gene Name thyrotropin-releasing hormone receptor
Synonyms TRH-R
Species Homo sapiens
Ensembl Gene ENSG00000174417
Encoded Proteins
IDBP-32512
thyrotropin-releasing hormone receptor
IDBP-479929
thyrotropin-releasing hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:109086621-109119584
Strand Forward strand
Band q23.1
Transcripts
ENST00000311762 ENSP00000309818
ENST00000518632 ENSP00000430711
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004997 thyrotropin-releasing hormone receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038760
View Gene Order
ENSBTAG00000019997
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt P34981
TrEMBL
UniProt Splice Variant
Entrez Gene 7201
UniGene Hs.3022
RefSeq NM_003301
HUGO HGNC:12299
OMIM 188545
CCDS CCDS6311
HPRD 11767
IMGT
EMBL AJ011701 AY493373 BC105045 BC113360 D16845 D85376 S75281 S75283 X72089 X75071
GenPept AAB32222 AAI05046 AAI13361 AAR84356 BAA04120 BAA12796 CAA09746 CAA50979 CAA52965
RNA Seq Atlas 7201

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca