Version 5.4
Homo sapiens Gene: IL27RA
Summary
InnateDB Gene IDBG-32723.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL27RA
Gene Name interleukin 27 receptor, alpha
Synonyms CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1
Species Homo sapiens
Ensembl Gene ENSG00000104998
Encoded Proteins
IDBP-32725
interleukin 27 receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14031748-14053216
Strand Forward strand
Band p13.12
Transcripts
ENST00000263379 ENSP00000263379
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0045509 interleukin-27 receptor activity
Biological Process
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0032729 positive regulation of interferon-gamma production
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050830 defense response to Gram-positive bacterium
GO:0070106 interleukin-27-mediated signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005465
View Gene Order
ENSBTAG00000016933
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
il27pathway
IL27-mediated signaling events
Cross-References
SwissProt Q6UWB1
TrEMBL
UniProt Splice Variant
Entrez Gene 9466
UniGene Hs.132781 Hs.626408
RefSeq NM_004843
HUGO HGNC:17290
OMIM 605350
CCDS CCDS12303
HPRD
IMGT
EMBL AF053004 AF106912 AF265242 AY358876 BC028003 EF064719
GenPept AAC39755 AAG26090 AAG27297 AAH28003 AAQ89235 ABK41902
RNA Seq Atlas 9466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca