Version 5.4
Homo sapiens Gene: PALM3
Summary
InnateDB Gene IDBG-32847.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PALM3
Gene Name paralemmin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000187867
Encoded Proteins
IDBP-32849
paralemmin 3
IDBP-761334
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21187075
PALM3 is a LPS inducible gene that functions as an adaptor protein for TLR4 signalling. PALM3 interacts with SIGIRR to negatively regulate TLR signalling.
InnateDB Annotation from Orthologs
Summary
PMID 21187075
[Mus musculus] Palm3 is a LPS inducible gene that functions as an adaptor protein for Tlr4 signaling. Palm3 interacts with Sigirr to negatively regulate TLR signaling.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14053365-14059159
Strand Reverse strand
Band p13.12
Transcripts
ENST00000340790 ENSP00000344996
ENST00000586368
ENST00000589048 ENSP00000465701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0008063 Toll signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000047986
View Gene Order
ENSBTAG00000046744
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444298 Hs.622396
RefSeq NM_001145028 XM_005259891
HUGO
OMIM
CCDS CCDS46001
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca