Homo sapiens Gene: MUC17

Summary
InnateDB Gene IDBG-32878.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol MUC17
Gene Name mucin 17, cell surface associated
Synonyms MUC3
Species Homo sapiens
Ensembl Gene ENSG00000169876
Encoded Proteins
IDBP-32880 mucin 17, cell surface associated
IDBP-32882 mucin 17, cell surface associated
Entrez Gene
Summary Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 7: 100663353-100702020
Strand Forward strand
Band q22.1
Transcripts
ENST00000306151  ENSP00000302716
ENST00000379439  ENSP00000368751
ENST00000470303 
ENST00000497859 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0030165 PDZ domain binding
GO:0030197 extracellular matrix constituent, lubricant activity
Biological Process
GO:0010812 negative regulation of cell-substrate adhesion
GO:0016266 O-glycan processing
GO:0019725 cellular homeostasis
GO:0022408 negative regulation of cell-cell adhesion
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016021 integral to membrane
GO:0016324 apical plasma membrane
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000037390 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
REACT_115606 O-linked glycosylation of mucins
REACT_115835 Termination of O-glycan biosynthesis
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q685J3 
TrEMBL A1A4F7 E7EPM4
UniProt Splice Variant
Entrez Gene 140453 
UniGene Hs.271819
RefSeq NM_001040105 
HUGO 16800 
OMIM 608424
CCDS CCDS34711 
HPRD 16335
IMGT
EMBL AC105446 AF016693 AF430017 AJ606307 AJ606308 BC126315
GenPept AAB71686  AAI26316  AAL89737  CAE54435  CAE54436 
ImmGen MUC17 (murine) 
RNA Seq Atlas 140453