Version 5.4
Homo sapiens Gene: INTS12
Summary
InnateDB Gene IDBG-33032.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS12
Gene Name integrator complex subunit 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138785
Encoded Proteins
IDBP-33034
integrator complex subunit 12
IDBP-240982
integrator complex subunit 12
IDBP-375410
integrator complex subunit 12
IDBP-375411
integrator complex subunit 12
IDBP-375412
integrator complex subunit 12
IDBP-375413
integrator complex subunit 12
IDBP-482650
integrator complex subunit 12
IDBP-476116
integrator complex subunit 12
IDBP-474051
integrator complex subunit 12
IDBP-812408
integrator complex subunit 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary INTS12 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:105682627-105895986
Strand Reverse strand
Band q24
Transcripts
ENST00000340139 ENSP00000340737
ENST00000394735 ENSP00000378221
ENST00000451321 ENSP00000415433
ENST00000420368 ENSP00000412317
ENST00000416543 ENSP00000396309
ENST00000433009 ENSP00000396729
ENST00000493425
ENST00000503746 ENSP00000423618
ENST00000510876 ENSP00000422856
ENST00000515819 ENSP00000422048
ENST00000618810 ENSP00000481164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028016
View Gene Order
ENSBTAG00000033648
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.480454
RefSeq NM_001142471 NM_020395 XM_005263149
HUGO
OMIM
CCDS CCDS3671
HPRD 11271
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca