Version 5.4
Homo sapiens Gene: TFCP2
Summary
InnateDB Gene IDBG-33112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFCP2
Gene Name transcription factor CP2
Synonyms LBP1C; LSF; LSF1D; SEF; TFCP2C
Species Homo sapiens
Ensembl Gene ENSG00000135457
Encoded Proteins
IDBP-33114
transcription factor CP2
IDBP-600317
transcription factor CP2
IDBP-592596
transcription factor CP2
IDBP-585588
transcription factor CP2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer\'s disease. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:51093663-51173134
Strand Reverse strand
Band q13.13
Transcripts
ENST00000257915 ENSP00000257915
ENST00000549867 ENSP00000449742
ENST00000546822
ENST00000548115 ENSP00000447991
ENST00000548108 ENSP00000449280
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009733
View Gene Order
ENSBTAG00000019312
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.48849 Hs.715085
RefSeq NM_001173452 NM_001173453 NM_005653
HUGO
OMIM
CCDS CCDS55827 CCDS8808
HPRD 01790
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca