Version 5.4
Homo sapiens Gene: ARL2BP
Summary
InnateDB Gene IDBG-33127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARL2BP
Gene Name ADP-ribosylation factor-like 2 binding protein
Synonyms BART; BART1; RP66
Species Homo sapiens
Ensembl Gene ENSG00000102931
Encoded Proteins
IDBP-33129
ADP-ribosylation factor-like 2 binding protein
IDBP-746318
IDBP-753046
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57245098-57253635
Strand Forward strand
Band q13
Transcripts
ENST00000219204 ENSP00000219204
ENST00000562023 ENSP00000457465
ENST00000563234 ENSP00000454237
ENST00000565794
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0050790 regulation of catalytic activity
GO:0051457 maintenance of protein location in nucleus
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005813 centrosome
GO:0005819 spindle
GO:0005929 cilium
GO:0030496 midbody
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031776
View Gene Order
ENSBTAG00000004844
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632873 Hs.743626
RefSeq NM_012106
HUGO
OMIM
CCDS CCDS10776
HPRD 09808
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca