Version 5.4
Homo sapiens Gene: PLOD3
Summary
InnateDB Gene IDBG-33147.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLOD3
Gene Name procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Synonyms LH3
Species Homo sapiens
Ensembl Gene ENSG00000106397
Encoded Proteins
IDBP-33149
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384165
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384174
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384177
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384181
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384183
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
IDBP-384186
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:101205977-101218420
Strand Reverse strand
Band q22.1
Transcripts
ENST00000223127 ENSP00000223127
ENST00000454310 ENSP00000407555
ENST00000440925 ENSP00000394045
ENST00000421736 ENSP00000407908
ENST00000424135 ENSP00000404799
ENST00000414785 ENSP00000407551
ENST00000456079 ENSP00000416070
ENST00000487563
ENST00000460132
ENST00000466881
ENST00000463479
ENST00000478082
ENST00000460475
ENST00000478264
ENST00000489927
ENST00000481461
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 26 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008475 procollagen-lysine 5-dioxygenase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
GO:0033823 procollagen glucosyltransferase activity
GO:0050211 procollagen galactosyltransferase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0001886 endothelial cell morphogenesis
GO:0006464 cellular protein modification process
GO:0008104 protein localization
GO:0021915 neural tube development
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0032870 cellular response to hormone stimulus
GO:0042311 vasodilation
GO:0048730 epidermis morphogenesis
GO:0055114 oxidation-reduction process
GO:0060425 lung morphogenesis
GO:0070831 basement membrane assembly
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004846
View Gene Order
ENSBTAG00000000342
Not yet available
Pathways
NETPATH
REACTOME
REACT_121139
Collagen biosynthesis and modifying enzymes pathway
REACT_118779
Extracellular matrix organization pathway
REACT_120729
Collagen formation pathway
KEGG
hsa00310
Lysine degradation pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.153357 Hs.630415
RefSeq NM_001084
HUGO
OMIM
CCDS CCDS5715
HPRD 04347
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca