Version 5.4
Homo sapiens Gene: CCL22
Summary
InnateDB Gene IDBG-33170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCL22
Gene Name chemokine (C-C motif) ligand 22
Synonyms ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1
Species Homo sapiens
Ensembl Gene ENSG00000102962
Encoded Proteins
IDBP-33172
chemokine (C-C motif) ligand 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Jul 2008]
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:57358772-57366190
Strand Forward strand
Band q21
Transcripts
ENST00000219235 ENSP00000219235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 13 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0009615 response to virus
GO:0060326 cell chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15344
Chemokine receptors bind chemokines pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04062
Chemokine signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O00626
TrEMBL
UniProt Splice Variant
Entrez Gene 6367
UniGene Hs.534347
RefSeq NM_002990
HUGO HGNC:10621
OMIM 602957
CCDS CCDS10778
HPRD
IMGT
EMBL AC004382 AC009052 AK311970 BC027952 CH471092 EF064764 U83171 U83239
GenPept AAB53372 AAB58360 AAC24306 AAH27952 ABK41947 BAG34909 EAW82918
RNA Seq Atlas 6367

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca