InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GPR98

Summary

InnateDB Gene

IDBG-33218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GPR98

Gene Name

G protein-coupled receptor 98

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164199

Encoded Proteins

IDBP-293833

G protein-coupled receptor 98

IDBP-373298

G protein-coupled receptor 98

IDBP-476723

G protein-coupled receptor 98

IDBP-483384

G protein-coupled receptor 98

IDBP-477329

G protein-coupled receptor 98

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:90529344-91164221

Strand

Forward strand

Band

q14.3

Transcripts

ENST00000405460	ENSP00000384582
ENST00000450321
ENST00000425867	ENSP00000392618
ENST00000508842	ENSP00000425936
ENST00000504142	ENSP00000424736
ENST00000512205
ENST00000509621	ENSP00000422153
ENST00000507314
ENST00000513828
ENST00000505845
ENST00000503852

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017022	myosin binding

Biological Process

GO:0007154	cell communication
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007399	nervous system development
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0016337	single organismal cell-cell adhesion
GO:0045494	photoreceptor cell maintenance
GO:0048496	maintenance of organ identity
GO:0048839	inner ear development
GO:0050877	neurological system process
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0050953	sensory perception of light stimulus
GO:0060122	inner ear receptor stereocilium organization

Cellular Component

GO:0002142	stereocilia ankle link complex
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000069170

View Gene Order

ENSBTAG00000006031

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.591777 Hs.613157

RefSeq

NM_032119

HUGO

OMIM

CCDS

CCDS47246

HPRD

09111

IMGT

EMBL

GenPept

RNA Seq Atlas