Version 5.4
Homo sapiens Gene: FKBP1B
Summary
InnateDB Gene IDBG-33239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FKBP1B
Gene Name FK506 binding protein 1B, 12.6 kDa
Synonyms FKBP12.6; FKBP1L; OTK4; PKBP1L; PPIase
Species Homo sapiens
Ensembl Gene ENSG00000119782
Encoded Proteins
IDBP-33241
FK506 binding protein 1B, 12.6 kDa
IDBP-33243
FK506 binding protein 1B, 12.6 kDa
IDBP-365911
FK506 binding protein 1B, 12.6 kDa
IDBP-365915
FK506 binding protein 1B, 12.6 kDa
IDBP-365918
FK506 binding protein 1B, 12.6 kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24049701-24063681
Strand Forward strand
Band p23.3
Transcripts
ENST00000380991 ENSP00000370379
ENST00000380986 ENSP00000370373
ENST00000438630 ENSP00000416349
ENST00000452109 ENSP00000406593
ENST00000421839 ENSP00000397444
ENST00000496149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005102 receptor binding
GO:0005219 ryanodine-sensitive calcium-release channel activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0019855 calcium channel inhibitor activity
GO:0030551 cyclic nucleotide binding
GO:0044325 ion channel binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0002027 regulation of heart rate
GO:0006457 protein folding
GO:0006458 'de novo' protein folding
GO:0006939 smooth muscle contraction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009749 response to glucose
GO:0010033 response to organic substance
GO:0010459 negative regulation of heart rate
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0019227 neuronal action potential propagation
GO:0022417 protein maturation by protein folding
GO:0030073 insulin secretion
GO:0032513 negative regulation of protein phosphatase type 2B activity
GO:0033197 response to vitamin E
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0042026 protein refolding
GO:0042098 T cell proliferation
GO:0042542 response to hydrogen peroxide
GO:0048680 positive regulation of axon regeneration
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051280 negative regulation of release of sequestered calcium ion into cytosol
GO:0051284 positive regulation of sequestering of calcium ion
GO:0051480 cytosolic calcium ion homeostasis
GO:0051775 response to redox state
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0061077 chaperone-mediated protein folding
GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070588 calcium ion transmembrane transport
GO:0086064 cell communication by electrical coupling involved in cardiac conduction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0033017 sarcoplasmic reticulum membrane
GO:0034704 calcium channel complex
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020635
View Gene Order
ENSBTAG00000003409
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004116 NM_054033
HUGO
OMIM
CCDS CCDS1706 CCDS33153
HPRD 02795
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca