Version 5.4
Homo sapiens Gene: PKN1
Summary
InnateDB Gene IDBG-33268.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKN1
Gene Name protein kinase N1
Synonyms DBK; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1
Species Homo sapiens
Ensembl Gene ENSG00000123143
Encoded Proteins
IDBP-33270
protein kinase N1
IDBP-33272
protein kinase N1
IDBP-765977
IDBP-763783
IDBP-765027
IDBP-764636
IDBP-764806
IDBP-764604
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18429822
PKN1 is a ubiquitously expressed kinase that, when phosphorylated by TRAF1, plays a critical role in the negative regulation of tonic activity of JNK and NF-kappaB signalling pathways.
Entrez Gene
Summary The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14433053-14471867
Strand Forward strand
Band p13.12
Transcripts
ENST00000242783 ENSP00000242783
ENST00000342216 ENSP00000343325
ENST00000592794
ENST00000586237 ENSP00000466819
ENST00000590097 ENSP00000466367
ENST00000586039
ENST00000586900
ENST00000587429
ENST00000585619 ENSP00000467422
ENST00000586557 ENSP00000465842
ENST00000588200
ENST00000587215
ENST00000592960 ENSP00000468497
ENST00000591461 ENSP00000465867
ENST00000585839
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 63 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004713 protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017049 GTP-Rho binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0042393 histone binding
GO:0042826 histone deacetylase binding
GO:0048365 Rac GTPase binding
GO:0050681 androgen receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006468 protein phosphorylation
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0007257 activation of JUN kinase activity
GO:0010631 epithelial cell migration
GO:0035407 histone H3-T11 phosphorylation
GO:0045087 innate immune response (InnateDB)
GO:2000145 regulation of cell motility
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030496 midbody
GO:0032154 cleavage furrow
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057672
View Gene Order
ENSBTAG00000017037
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
p38gammadeltapathway
Signaling mediated by p38-gamma and p38-delta
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
rhoa_pathway
RhoA signaling pathway
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466044
RefSeq NM_002741 NM_213560
HUGO
OMIM
CCDS CCDS42513 CCDS42514
HPRD 03019
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca