InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CELSR3

Summary

InnateDB Gene

IDBG-33330.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELSR3

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Synonyms

CDHF11; EGFL1; FMI1; HFMI1; MEGF2; RESDA1

Species

Homo sapiens

Ensembl Gene

ENSG00000008300

Encoded Proteins

IDBP-33342

cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:48636469-48662915

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000164024	ENSP00000164024
ENST00000461362
ENST00000498057
ENST00000470999

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0001764	neuron migration
GO:0007156	homophilic cell adhesion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007413	axonal fasciculation
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000023473

View Gene Order

ENSBTAG00000021846

Not yet available

Cross-References

SwissProt

Q9NYQ7

TrEMBL

B4DSQ9

UniProt Splice Variant

Entrez Gene

1951

UniGene

Hs.631926

RefSeq

NM_001407

HUGO

HGNC:3230

OMIM

604264

CCDS

CCDS2775

HPRD

IMGT

EMBL

AB011536 AC121252 AF231023 AK299868

GenPept

AAF61929 BAA32464 BAG61721

RNA Seq Atlas

1951