Version 5.4
Homo sapiens Gene: CYP2U1
Summary
InnateDB Gene IDBG-33398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP2U1
Gene Name cytochrome P450, family 2, subfamily U, polypeptide 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155016
Encoded Proteins
IDBP-33400
cytochrome P450, family 2, subfamily U, polypeptide 1
IDBP-478987
cytochrome P450, family 2, subfamily U, polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a hydroxylase that metabolizes arachidonic acid, docosahexaenoic acid, and other long chain fatty acids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:107931369-107953457
Strand Forward strand
Band q25
Transcripts
ENST00000332884 ENSP00000333212
ENST00000513302
ENST00000508453 ENSP00000423667
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0020037 heme binding
GO:0070330 aromatase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008219 cell death
GO:0019369 arachidonic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0097267 omega-hydroxylase P450 pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027983
View Gene Order
ENSBTAG00000012972
Not yet available
Pathways
NETPATH
REACTOME
REACT_150134
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_13425
Miscellaneous substrates pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.109087 Hs.611936 Hs.629594
RefSeq NM_183075
HUGO
OMIM
CCDS CCDS34047
HPRD 13109
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca