Homo sapiens Gene: HADH | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-33469.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | HADH | ||||||||||||||||||||
Gene Name | hydroxyacyl-CoA dehydrogenase | ||||||||||||||||||||
Synonyms | HAD; HADH1; HADHSC; HCDH; HHF4; MSCHAD; SCHAD | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000138796 | ||||||||||||||||||||
Encoded Proteins |
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
hydroxyacyl-CoA dehydrogenase
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
Summary |
This gene is a member of the 3-hydroxyacyl-CoA dehydrogenase gene family. The encoded protein functions in the mitochondrial matrix to catalyze the oxidation of straight-chain 3-hydroxyacyl-CoAs as part of the beta-oxidation pathway. Its enzymatic activity is highest with medium-chain-length fatty acids. Mutations in this gene cause one form of familial hyperinsulinemic hypoglycemia. The human genome contains a related pseudogene of this gene on chromosome 15. [provided by RefSeq, May 2010] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 4:107989714-108035175 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | q25 | ||||||||||||||||||||
Transcripts | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Beta oxidation of hexanoyl-CoA to butanoyl-CoA pathway
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA pathway
Beta oxidation of butanoyl-CoA to acetyl-CoA pathway
Beta oxidation of octanoyl-CoA to hexanoyl-CoA pathway
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial Fatty Acid Beta-Oxidation pathway
mitochondrial fatty acid beta-oxidation of saturated fatty acids pathway
Metabolism pathway
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KEGG |
Valine, leucine and isoleucine degradation pathway
Butanoate metabolism pathway
Tryptophan metabolism pathway
Fatty acid degradation pathway
Fatty acid elongation pathway
Lysine degradation pathway
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INOH |
Tryptophan degradation pathway
Butanoate metabolism pathway
Valine Leucine Isoleucine degradation pathway
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PID NCI |
FOXA2 and FOXA3 transcription factor networks
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Cross-References | |||||||||||||||||||||
SwissProt | |||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||
UniGene | Hs.438289 Hs.713095 | ||||||||||||||||||||
RefSeq | NM_001184705 NM_005327 XM_005262972 | ||||||||||||||||||||
HUGO | |||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS3678 CCDS54790 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | |||||||||||||||||||||
GenPept | |||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||