Version 5.4
Homo sapiens Gene: NDUFB7
Summary
InnateDB Gene IDBG-33550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFB7
Gene Name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
Synonyms B18; CI-B18
Species Homo sapiens
Ensembl Gene ENSG00000099795
Encoded Proteins
IDBP-33552
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa
IDBP-766248
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:14566078-14572062
Strand Reverse strand
Band p13.12
Transcripts
ENST00000215565 ENSP00000215565
ENST00000593353 ENSP00000473120
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0022904 respiratory electron transport chain
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0005758 mitochondrial intermembrane space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033938
View Gene Order
ENSBTAG00000012634
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt P17568
TrEMBL
UniProt Splice Variant
Entrez Gene 4713
UniGene
RefSeq NM_004146
HUGO HGNC:7702
OMIM 603842
CCDS CCDS12314
HPRD 11957
IMGT
EMBL AF112200 AF217091 BC002595 CH471106 CR450354 M33374
GenPept AAA35675 AAF17188 AAF91223 AAH02595 CAG29350 EAW84436
RNA Seq Atlas 4713

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca