Version 5.4
Homo sapiens Gene: FLII
Summary
InnateDB Gene IDBG-33698.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLII
Gene Name flightless I homolog (Drosophila)
Synonyms FLI; Fli1; FLIL
Species Homo sapiens
Ensembl Gene ENSG00000177731
Encoded Proteins
IDBP-33700
flightless I homolog (Drosophila)
IDBP-762626
IDBP-763116
IDBP-587192
flightless I homolog (Drosophila)
IDBP-761637
IDBP-758225
IDBP-758704
IDBP-761062
IDBP-761170
IDBP-764817
IDBP-763946
IDBP-759875
IDBP-761184
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:18244836-18258916
Strand Reverse strand
Band p11.2
Transcripts
ENST00000327031 ENSP00000324573
ENST00000465046
ENST00000487693
ENST00000487369
ENST00000474265
ENST00000493600
ENST00000493401
ENST00000459958
ENST00000496727
ENST00000488221
ENST00000488932 ENSP00000463838
ENST00000461110
ENST00000478416
ENST00000473425 ENSP00000467212
ENST00000545457 ENSP00000438536
ENST00000577398 ENSP00000468045
ENST00000578558 ENSP00000462314
ENST00000578101 ENSP00000462293
ENST00000579294 ENSP00000463534
ENST00000581858 ENSP00000465202
ENST00000581349 ENSP00000467199
ENST00000580453
ENST00000580966
ENST00000582626
ENST00000584444
ENST00000577402
ENST00000581401 ENSP00000462797
ENST00000577626 ENSP00000463902
ENST00000577485 ENSP00000463675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006936 muscle contraction
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002812
View Gene Order
ENSBTAG00000016161
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.513984 Hs.628115 Hs.704062
RefSeq NM_001256264 NM_001256265 NM_002018 XM_005256558
HUGO
OMIM
CCDS CCDS11192 CCDS58521 CCDS58522
HPRD 02647
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca