Version 5.4
Homo sapiens Gene: ENPP2
Summary
InnateDB Gene IDBG-33807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENPP2
Gene Name ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms ATX; ATX-X; AUTOTAXIN; LysoPLD; NPP2; PD-IALPHA; PDNP2
Species Homo sapiens
Ensembl Gene ENSG00000136960
Encoded Proteins
IDBP-33809
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-33811
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-375632
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-475452
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-478085
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-475740
ectonucleotide pyrophosphatase/phosphodiesterase 2
IDBP-483575
ectonucleotide pyrophosphatase/phosphodiesterase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5\' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:119557086-119673453
Strand Reverse strand
Band q24.12
Transcripts
ENST00000259486 ENSP00000259486
ENST00000075322 ENSP00000075322
ENST00000427067 ENSP00000403315
ENST00000523861
ENST00000522167 ENSP00000429476
ENST00000522826 ENSP00000428291
ENST00000518109
ENST00000520066 ENSP00000428304
ENST00000518958 ENSP00000429447
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003824 catalytic activity
GO:0004528 phosphodiesterase I activity
GO:0004551 nucleotide diphosphatase activity
GO:0004622 lysophospholipase activity
GO:0005044 scavenger receptor activity
GO:0005509 calcium ion binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008152 metabolic process
GO:0009395 phospholipid catabolic process
GO:0030334 regulation of cell migration
GO:0034638 phosphatidylcholine catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022425
View Gene Order
ENSBTAG00000013165
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00565
Ether lipid metabolism pathway
INOH
INOH website
Nicotinate Nicotinamide metabolism pathway
PID NCI
Cross-References
SwissProt Q13822
TrEMBL
UniProt Splice Variant
Entrez Gene 5168
UniGene Hs.190977 Hs.597357 Hs.741511
RefSeq NM_001130863 NM_001040092 NM_006209 XM_006716587
HUGO HGNC:3357
OMIM 601060
CCDS CCDS47914 CCDS34936 CCDS6329
HPRD 03037
IMGT
EMBL AC099818 AC107960 BC034961 D45421 D45914 EU131011 L35594 L46720
GenPept AAA64785 AAB00855 AAH34961 ABW38316 BAA08260 BAA08342
RNA Seq Atlas 5168

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca