Version 5.4
Homo sapiens Gene: NCOA1
Summary
InnateDB Gene IDBG-33884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCOA1
Gene Name nuclear receptor coactivator 1
Synonyms bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160; SRC1
Species Homo sapiens
Ensembl Gene ENSG00000084676
Encoded Proteins
IDBP-33886
nuclear receptor coactivator 1
IDBP-33888
nuclear receptor coactivator 1
IDBP-238703
nuclear receptor coactivator 1
IDBP-294861
nuclear receptor coactivator 1
IDBP-294854
nuclear receptor coactivator 1
IDBP-294848
nuclear receptor coactivator 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24491914-24770702
Strand Forward strand
Band p23.3
Transcripts
ENST00000288599 ENSP00000288599
ENST00000348332 ENSP00000320940
ENST00000395856 ENSP00000379197
ENST00000406961 ENSP00000385216
ENST00000405141 ENSP00000385097
ENST00000407230 ENSP00000385195
ENST00000496333
ENST00000469850
ENST00000483904
ENST00000486198
ENST00000493773
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 169 [view]
Protein-Protein 150 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 10 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001012 RNA polymerase II regulatory region DNA binding
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0004402 histone acetyltransferase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0019899 enzyme binding
GO:0030331 estrogen receptor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0032403 protein complex binding
GO:0033142 progesterone receptor binding
GO:0035257 nuclear hormone receptor binding
GO:0042974 retinoic acid receptor binding
GO:0046965 retinoid X receptor binding
GO:0046983 protein dimerization activity
GO:0047485 protein N-terminus binding
GO:0050681 androgen receptor binding
Biological Process
GO:0000435 positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0007595 lactation
GO:0008584 male gonad development
GO:0009725 response to hormone
GO:0016573 histone acetylation
GO:0021549 cerebellum development
GO:0021766 hippocampus development
GO:0021854 hypothalamus development
GO:0021987 cerebral cortex development
GO:0030521 androgen receptor signaling pathway
GO:0032355 response to estradiol
GO:0032526 response to retinoic acid
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0042698 ovulation cycle
GO:0043065 positive regulation of apoptotic process
GO:0043967 histone H4 acetylation
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045925 positive regulation of female receptivity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060179 male mating behavior
GO:0060206 estrous cycle phase
GO:0060713 labyrinthine layer morphogenesis
GO:2001038 regulation of cellular response to drug
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020647
View Gene Order
ENSBTAG00000015007
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_18
IL6 pathway
NetPath_22
Leptin pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_13812
Endogenous sterols pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_71
Gene Expression pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
erb_genomic_pathway
Validated nuclear estrogen receptor beta network
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
hes_heypathway
Notch-mediated HES/HEY network
reg_gr_pathway
Glucocorticoid receptor regulatory network
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt Q15788
TrEMBL
UniProt Splice Variant
Entrez Gene 8648
UniGene Hs.596314 Hs.644297 Hs.733185
RefSeq NM_003743 NM_147223 NM_147233 XM_005264625 XM_005264626 XM_005264627 XM_005264628
HUGO HGNC:7668
OMIM 602691
CCDS CCDS1712 CCDS1713 CCDS42660
HPRD 04070
IMGT
EMBL AC013459 AC093798 AJ000881 AJ000882 AY633656 BC111533 BC111534 CH471053 EF660499 U19179 U40396 U59302 U90661
GenPept AAA64187 AAB50242 AAC50305 AAC50631 AAI11534 AAI11535 AAT47737 AAX93184 ABS29266 CAA04371 CAA04372 EAX00746
RNA Seq Atlas 8648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca