Version 5.4
Homo sapiens Gene: P4HTM
Summary
InnateDB Gene IDBG-33889.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol P4HTM
Gene Name prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178467
Encoded Proteins
IDBP-33891
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
IDBP-33895
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
IDBP-376660
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
IDBP-809486
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
IDBP-809489
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
IDBP-809492
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:48989886-49007154
Strand Forward strand
Band p21.31
Transcripts
ENST00000343546 ENSP00000341422
ENST00000383729 ENSP00000373235
ENST00000444213 ENSP00000398554
ENST00000472301
ENST00000484115
ENST00000475629 ENSP00000477191
ENST00000468374
ENST00000486817
ENST00000485210
ENST00000491739 ENSP00000476303
ENST00000472796 ENSP00000476858
ENST00000609406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000006675
View Gene Order
ENSBTAG00000005490
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654944
RefSeq NM_177938 NM_177939
HUGO
OMIM
CCDS CCDS2781 CCDS43089
HPRD 17842
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca