Version 5.4
Homo sapiens Gene: WDR6
Summary
InnateDB Gene IDBG-33969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WDR6
Gene Name WD repeat domain 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000178252
Encoded Proteins
IDBP-239482
WD repeat domain 6
IDBP-810722
WD repeat domain 6
IDBP-376682
WD repeat domain 6
IDBP-376684
WD repeat domain 6
IDBP-376687
WD repeat domain 6
IDBP-376688
WD repeat domain 6
IDBP-376689
WD repeat domain 6
IDBP-376690
WD repeat domain 6
IDBP-810729
WD repeat domain 6
IDBP-810730
WD repeat domain 6
IDBP-810724
WD repeat domain 6
IDBP-810733
WD repeat domain 6
IDBP-810734
WD repeat domain 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. The encoded protein interacts with serine/threonine kinase 11, and is implicated in cell growth arrest. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49007062-49015953
Strand Forward strand
Band p21.31
Transcripts
ENST00000395474 ENSP00000378857
ENST00000429900 ENSP00000477418
ENST00000420783 ENSP00000395993
ENST00000415265 ENSP00000412195
ENST00000438660 ENSP00000387692
ENST00000452875 ENSP00000414157
ENST00000448293 ENSP00000413432
ENST00000419837 ENSP00000390740
ENST00000488572
ENST00000462064
ENST00000489684
ENST00000473238
ENST00000471162
ENST00000472878
ENST00000461687
ENST00000489427 ENSP00000477087
ENST00000491365 ENSP00000477463
ENST00000498023
ENST00000492780
ENST00000608424 ENSP00000477389
ENST00000610967 ENSP00000484799
ENST00000615452 ENSP00000482289
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0043560 insulin receptor substrate binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation
GO:0010507 negative regulation of autophagy
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008180 COP9 signalosome
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066357
View Gene Order
ENSBTAG00000018910
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654815 Hs.694641
RefSeq NM_018031 XM_005264837
HUGO
OMIM
CCDS CCDS2782
HPRD 06912
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca