InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NR4A1

Summary

InnateDB Gene

IDBG-33982.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NR4A1

Gene Name

nuclear receptor subfamily 4, group A, member 1

Synonyms

GFRP1; HMR; N10; NAK-1; NGFIB; NP10; NUR77; TR3

Species

Homo sapiens

Ensembl Gene

ENSG00000123358

Encoded Proteins

IDBP-33984

nuclear receptor subfamily 4, group A, member 1

IDBP-33986

nuclear receptor subfamily 4, group A, member 1

IDBP-240797

nuclear receptor subfamily 4, group A, member 1

IDBP-240799

nuclear receptor subfamily 4, group A, member 1

IDBP-717400

IDBP-718034

IDBP-718367

IDBP-597689

nuclear receptor subfamily 4, group A, member 1

IDBP-597777

nuclear receptor subfamily 4, group A, member 1

IDBP-590292

nuclear receptor subfamily 4, group A, member 1

IDBP-602772

nuclear receptor subfamily 4, group A, member 1

IDBP-717761

IDBP-717900

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:52022832-52059507

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000360284	ENSP00000353427
ENST00000243050	ENSP00000243050
ENST00000394825	ENSP00000378302
ENST00000394824	ENSP00000378301
ENST00000478250
ENST00000548977	ENSP00000456633
ENST00000546842	ENSP00000457070
ENST00000553200	ENSP00000456776
ENST00000545748	ENSP00000440864
ENST00000550082	ENSP00000449539
ENST00000549102
ENST00000547206
ENST00000550763	ENSP00000449858
ENST00000548232	ENSP00000449587
ENST00000548733
ENST00000550557
ENST00000550339
ENST00000550582	ENSP00000455767
ENST00000567890
ENST00000562373	ENSP00000455399
ENST00000565848
ENST00000564201

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 124 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	124 [view]
Protein-Protein	122 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0030522	intracellular receptor signaling pathway
GO:0035767	endothelial cell chemotaxis
GO:0035914	skeletal muscle cell differentiation
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043065	positive regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043401	steroid hormone mediated signaling pathway
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0071310	cellular response to organic substance