Version 5.4
Homo sapiens Gene: CENPO
Summary
InnateDB Gene IDBG-34046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CENPO
Gene Name centromere protein O
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138092
Encoded Proteins
IDBP-34048
centromere protein O
IDBP-34050
centromere protein O
IDBP-483504
centromere protein O
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24793136-24822376
Strand Forward strand
Band p23.3
Transcripts
ENST00000380834 ENSP00000370214
ENST00000260662 ENSP00000260662
ENST00000395845
ENST00000473476
ENST00000473706 ENSP00000417787
ENST00000491031
ENST00000486527
ENST00000498362
ENST00000464156
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 14 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0000278 mitotic cell cycle
GO:0006334 nucleosome assembly
GO:0034080 centromere-specific nucleosome assembly
GO:0034508 centromere complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020652
View Gene Order
ENSBTAG00000015014
Not yet available
Pathways
NETPATH
REACTOME
REACT_22186
Deposition of new CENPA-containing nucleosomes at the centromere pathway
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_22172
Chromosome Maintenance pathway
REACT_22344
Nucleosome assembly pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9BU64
TrEMBL
UniProt Splice Variant
Entrez Gene 79172
UniGene Hs.731569 Hs.732476
RefSeq XM_006712102 NM_001199803 NM_024322
HUGO HGNC:28152
OMIM 611504
CCDS CCDS1714 CCDS56113
HPRD 14414
IMGT
EMBL AC012073 AC013459 AK027859 AK315483 BC002870 CH471053
GenPept AAH02870 AAY14786 BAB55414 BAG37867 EAX00742 EAX00743
RNA Seq Atlas 79172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca