Version 5.4
| Homo sapiens Gene: QARS | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-34287.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | QARS | ||||||||||||||||||
| Gene Name | glutaminyl-tRNA synthetase | ||||||||||||||||||
| Synonyms | GLNRS; MSCCA; PRO2195 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000172053 | ||||||||||||||||||
| Encoded Proteins |
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
glutaminyl-tRNA synthetase
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 3:49095932-49105101 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p21.31 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Mitochondrial tRNA aminoacylation pathway
Cytosolic tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
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| KEGG |
Aminoacyl-tRNA biosynthesis pathway
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| INOH |
Glutamate Glutamine metabolism pathway
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| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| UniGene | Hs.630416 Hs.79322 | ||||||||||||||||||
| RefSeq | NM_001272073 NM_005051 | ||||||||||||||||||
| HUGO | |||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS2788 CCDS63633 | ||||||||||||||||||
| HPRD | 07223 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | |||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||