InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: POMC

Summary

InnateDB Gene

IDBG-34380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POMC

Gene Name

proopiomelanocortin

Synonyms

ACTH; CLIP; LPH; MSH; NPP; POC

Species

Homo sapiens

Ensembl Gene

ENSG00000115138

Encoded Proteins

IDBP-34382

proopiomelanocortin

IDBP-34384

proopiomelanocortin

IDBP-238766

proopiomelanocortin

IDBP-294812

proopiomelanocortin

IDBP-366907

proopiomelanocortin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:25160853-25168903

Strand

Reverse strand

Band

p23.3

Transcripts

ENST00000380794	ENSP00000370171
ENST00000264708	ENSP00000264708
ENST00000395826	ENSP00000379170
ENST00000405623	ENSP00000384092
ENST00000449220	ENSP00000387993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0008217	regulation of blood pressure
GO:0016486	peptide hormone processing
GO:0032098	regulation of appetite
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033059	cellular pigmentation
GO:0042593	glucose homeostasis
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070873	regulation of glycogen metabolic process
GO:2000852	regulation of corticosterone secretion

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0030141	secretory granule
GO:0034774	secretory granule lumen

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020660

View Gene Order

ENSBTAG00000007897

Not yet available

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_19327

G alpha (s) signalling events pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_15457

G-protein activation pathway

REACT_15295

Opioid Signalling pathway

REACT_15452

Peptide hormone biosynthesis pathway

REACT_11036

Glucocorticoid biosynthesis pathway

REACT_11059

Androgen biosynthesis pathway

REACT_13812

Endogenous sterols pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_14797

Signaling by GPCR pathway

REACT_11057

Metabolism of steroid hormones and vitamin D pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_13567

Cytochrome P450 - arranged by substrate type pathway

REACT_17015

Metabolism of proteins pathway

REACT_21340

GPCR ligand binding pathway

REACT_111217

Metabolism pathway

REACT_160078

Peptide hormone metabolism pathway

REACT_13433

Biological oxidations pathway

REACT_13705

Phase 1 - Functionalization of compounds pathway

KEGG

hsa04920

Adipocytokine signaling pathway pathway

hsa04916

Melanogenesis pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

reg_gr_pathway

Glucocorticoid receptor regulatory network

syndecan_3_pathway

Syndecan-3-mediated signaling events

Cross-References

SwissProt

P01189

TrEMBL

A6XND7 E9PHK5 K7QX47 K7QZC2 K7QZC9 K7R2I7 K7R2J5 Q53WY7

UniProt Splice Variant

Entrez Gene

5443

UniGene

RefSeq

NM_000939 NM_001035256

HUGO

HGNC:9201

OMIM

176830

CCDS

CCDS1717

HPRD

01462

IMGT

EMBL

AC012457 BC065832 CH471053 DQ884404 J00291 J00292 JX003302 JX003303 JX003304 JX003309 JX003311 JX003313 JX003314 JX003316 JX003317 JX003321 M25896 M38297 S76492 V01510

GenPept

AAA35799 AAA60140 AAB59621 AAC60644 AAH65832 AAY24354 ABI63371 AFV77533 AFV77534 AFV77535 AFV77538 AFV77540 AFV77542 AFV77543 AFV77545 AFV77546 AFV77550 CAA24754 EAX00729 EAX00730

RNA Seq Atlas

5443