Version 5.4
Homo sapiens Gene: BRD4
Summary
InnateDB Gene IDBG-34500.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRD4
Gene Name bromodomain containing 4
Synonyms CAP; HUNK1; HUNKI; MCAP
Species Homo sapiens
Ensembl Gene ENSG00000141867
Encoded Proteins
IDBP-34502
bromodomain containing 4
IDBP-34504
bromodomain containing 4
IDBP-91677
bromodomain containing 4
IDBP-760227
IDBP-765916
IDBP-766021
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15235519-15332545
Strand Reverse strand
Band p13.12
Transcripts
ENST00000263377 ENSP00000263377
ENST00000360016 ENSP00000353112
ENST00000371835 ENSP00000360901
ENST00000601941 ENSP00000471240
ENST00000601071
ENST00000594841 ENSP00000470481
ENST00000602230
ENST00000595926
ENST00000594066
ENST00000594842
ENST00000597315 ENSP00000470108
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 103 [view]
Protein-Protein 83 [view]
Protein-DNA 19 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0070577 lysine-acetylated histone binding
Biological Process
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001833 inner cell mass cell proliferation
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007059 chromosome segregation
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043388 positive regulation of DNA binding
GO:0043983 histone H4-K12 acetylation
GO:0044154 histone H3-K14 acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050727 regulation of inflammatory response
GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:2000002 negative regulation of DNA damage checkpoint
Cellular Component
GO:0000790 nuclear chromatin
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0008024 positive transcription elongation factor complex b
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024002
View Gene Order
ENSBTAG00000002495
Not yet available
Pathways
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.187763 Hs.610415
RefSeq NM_014299 NM_058243
HUGO
OMIM
CCDS CCDS12328 CCDS46004
HPRD 10574
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca