Version 5.4
| Homo sapiens Gene: KRT6B | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-34557.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | KRT6B | ||||||||||||||||||
| Gene Name | keratin 6B | ||||||||||||||||||
| Synonyms | CK-6B; CK6B; K6B; KRTL1; PC2; PC4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000185479 | ||||||||||||||||||
| Encoded Proteins |
keratin 6B
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 12:52446651-52452126 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q13.13 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P04259 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 3854 | ||||||||||||||||||
| UniGene | Hs.708950 | ||||||||||||||||||
| RefSeq | NM_005555 | ||||||||||||||||||
| HUGO | HGNC:6444 | ||||||||||||||||||
| OMIM | 148042 | ||||||||||||||||||
| CCDS | CCDS8828 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC055736 BC034535 L00198 L00199 L00200 L00201 L00202 L00203 L00204 L00205 L42584 L42585 L42586 L42587 L42588 L42589 L42590 L42592 L42612 M11229 | ||||||||||||||||||
| GenPept | AAA59466 AAC41768 AAC41771 AAH34535 | ||||||||||||||||||
| RNA Seq Atlas | 3854 | ||||||||||||||||||