Version 5.4
Homo sapiens Gene: ZHX1
Summary
InnateDB Gene IDBG-34656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZHX1
Gene Name zinc fingers and homeoboxes 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165156
Encoded Proteins
IDBP-34658
zinc fingers and homeoboxes 1
IDBP-239293
zinc fingers and homeoboxes 1
IDBP-473717
zinc fingers and homeoboxes 1
IDBP-809821
zinc fingers and homeoboxes 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 8 open reading frame 76 (C8orf76) gene. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:123248451-123275541
Strand Reverse strand
Band q24.13
Transcripts
ENST00000297857 ENSP00000297857
ENST00000395571 ENSP00000378938
ENST00000517516
ENST00000522655 ENSP00000428821
ENST00000522595
ENST00000524267
ENST00000480132
ENST00000602651 ENSP00000475324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0030154 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022361
View Gene Order
ENSBTAG00000015334
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001017926 NM_007222
HUGO
OMIM
CCDS CCDS6342
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca