Version 5.4
Homo sapiens Gene: RHOA
Summary
InnateDB Gene IDBG-34732.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHOA
Gene Name ras homolog family member A
Synonyms ARH12; ARHA; RHO12; RHOH12
Species Homo sapiens
Ensembl Gene ENSG00000067560
Encoded Proteins
IDBP-377198
ras homolog gene family, member A
IDBP-377199
ras homolog gene family, member A
IDBP-377200
ras homolog gene family, member A
IDBP-377201
ras homolog gene family, member A
IDBP-377203
ras homolog gene family, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49359145-49412998
Strand Reverse strand
Band p21.31
Transcripts
ENST00000265538
ENST00000418115 ENSP00000400175
ENST00000454011 ENSP00000394483
ENST00000422781 ENSP00000413587
ENST00000445425 ENSP00000408402
ENST00000431929 ENSP00000400747
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 171 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 171 [view]
Protein-Protein 169 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017022 myosin binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0015031 protein transport
GO:0016032 viral process
GO:0021762 substantia nigra development
GO:0030036 actin cytoskeleton organization
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0032467 positive regulation of cytokinesis
GO:0033688 regulation of osteoblast proliferation
GO:0036089 cleavage furrow formation
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043297 apical junction assembly
GO:0043931 ossification involved in bone maturation
GO:0045666 positive regulation of neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051496 positive regulation of stress fiber assembly
GO:0061383 trabecula morphogenesis
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0043296 apical junction complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007815
View Gene Order
ENSBTAG00000004279
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
NetPath_23
TSH pathway
REACTOME
REACT_1695
GPVI-mediated activation cascade pathway
REACT_12464
PI3K/AKT activation pathway
REACT_13779
Axonal growth stimulation pathway
REACT_13815
Axonal growth inhibition (RHOA activation) pathway
REACT_19290
G beta:gamma signalling through PI3Kgamma pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_172581
PCP/CE pathway pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_13620
p75NTR regulates axonogenesis pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_19388
G-protein beta:gamma signalling pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa04510
Focal adhesion pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04144
Endocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa04972
Pancreatic secretion pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
epha_fwdpathway
EPHA forward signaling
txa2pathway
Thromboxane A2 receptor signaling
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kcipathway
Class I PI3K signaling events
s1p_s1p1_pathway
S1P1 pathway
lysophospholipid_pathway
LPA receptor mediated events
il2_1pathway
IL2-mediated signaling events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
s1p_s1p2_pathway
S1P2 pathway
ptp1bpathway
Signaling events mediated by PTP1B
thrombin_par1_pathway
PAR1-mediated thrombin signaling events
fak_pathway
Signaling events mediated by focal adhesion kinase
rhoa_reg_pathway
Regulation of RhoA activity
p75ntrpathway
p75(NTR)-mediated signaling
prlsignalingeventspathway
Signaling events mediated by PRL
s1p_s1p5_pathway
S1P5 pathway
s1p_s1p3_pathway
S1P3 pathway
s1p_s1p4_pathway
S1P4 pathway
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
syndecan_4_pathway
Syndecan-4-mediated signaling events
er_nongenomic_pathway
Plasma membrane estrogen receptor signaling
thrombin_par4_pathway
PAR4-mediated thrombin signaling events
ret_pathway
Signaling events regulated by Ret tyrosine kinase
shp2_pathway
SHP2 signaling
arf6downstreampathway
Arf6 downstream pathway
rhoa_pathway
RhoA signaling pathway
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
epha2_fwdpathway
EPHA2 forward signaling
aurora_b_pathway
Aurora B signaling
a4b7_pathway
a4b7 Integrin signaling
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
pdgfrbpathway
PDGFR-beta signaling pathway
amb2_neutrophils_pathway
amb2 Integrin signaling
toll_endogenous_pathway
Endogenous TLR signaling
ncadherinpathway
N-cadherin signaling events
plk1_pathway
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.247077
RefSeq NM_001664
HUGO
OMIM
CCDS CCDS2795
HPRD 01323
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca