Homo sapiens Gene: CDH11
Summary
InnateDB Gene IDBG-34793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDH11
Gene Name cadherin 11, type 2, OB-cadherin (osteoblast)
Synonyms CAD11; CDHOB; OB; OSF-4
Species Homo sapiens
Ensembl Gene ENSG00000140937
Encoded Proteins
cadherin 11, type 2, OB-cadherin (osteoblast)
cadherin 11, type 2, OB-cadherin (osteoblast)
cadherin 11, type 2, OB-cadherin (osteoblast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:64943753-65126112
Strand Reverse strand
Band q21
Transcripts
ENST00000268603 ENSP00000268603
ENST00000394156 ENSP00000377711
ENST00000566827 ENSP00000457812
ENST00000565210
ENST00000562712 ENSP00000455120
ENST00000564317 ENSP00000456772
ENST00000569095
ENST00000562998 ENSP00000455420
ENST00000567934 ENSP00000455779
ENST00000569624
ENST00000562325 ENSP00000456110
ENST00000562882 ENSP00000455697
ENST00000569128
ENST00000569783
ENST00000563255
ENST00000564770
ENST00000568340
ENST00000563492
ENST00000619158 ENSP00000484650
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion
GO:0021957 corticospinal tract morphogenesis
GO:0034329 cell junction assembly
GO:0034332 adherens junction organization
GO:0045216 cell-cell junction organization
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Adherens junctions interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.116471
RefSeq NM_001797 XM_005255761 XM_005255762 XM_005255763 XM_005255764 XM_005255766 XM_005255767
HUGO
OMIM
CCDS CCDS10803
HPRD 08960
IMGT
EMBL
GenPept
RNA Seq Atlas