InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP4F3

Summary

InnateDB Gene

IDBG-34860.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4F3

Gene Name

cytochrome P450, family 4, subfamily F, polypeptide 3

Synonyms

CPF3; CYP4F; LTB4H

Species

Homo sapiens

Ensembl Gene

ENSG00000186529

Encoded Proteins

IDBP-34903

cytochrome P450, family 4, subfamily F, polypeptide 3

IDBP-761451

IDBP-765482

IDBP-764677

IDBP-808372

cytochrome P450, family 4, subfamily F, polypeptide 3

IDBP-760356

IDBP-808376

cytochrome P450, family 4, subfamily F, polypeptide 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15615617-15662825

Strand

Forward strand

Band

p13.12

Transcripts

ENST00000221307	ENSP00000221307
ENST00000586182	ENSP00000466395
ENST00000587360	ENSP00000465394
ENST00000585846	ENSP00000468105
ENST00000592424	ENSP00000476546
ENST00000591058	ENSP00000466988
ENST00000592279
ENST00000609670
ENST00000620621	ENSP00000478605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0052871	alpha-tocopherol omega-hydroxylase activity

Biological Process

GO:0006690	icosanoid metabolic process
GO:0006691	leukotriene metabolic process
GO:0006805	xenobiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0036101	leukotriene B4 catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process