Homo sapiens Gene: PCK2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-3497.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | PCK2 | ||||||||||||||||||||||
Gene Name | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | ||||||||||||||||||||||
Synonyms | PEPCK; PEPCK-M; PEPCK2 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000100889 | ||||||||||||||||||||||
Encoded Proteins |
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a member of the phosphoenolpyruvate carboxykinase (GTP) family. The protein is a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of GTP. A cytosolic form encoded by a different gene has also been characterized and is the key enzyme of gluconeogenesis in the liver. The encoded protein may serve a similar function, although it is constitutively expressed and not modulated by hormones such as glucagon and insulin that regulate the cytosolic form. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:24094053-24110598 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q11.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Gluconeogenesis pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
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KEGG |
Glycolysis / Gluconeogenesis pathway
Pyruvate metabolism pathway
Citrate cycle (TCA cycle) pathway
Insulin signaling pathway pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Proximal tubule bicarbonate reclamation pathway
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INOH |
Citrate cycle pathway
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PID NCI |
Glucocorticoid receptor regulatory network
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.75812 | ||||||||||||||||||||||
RefSeq | NM_001018073 NM_001291556 NM_004563 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS41928 CCDS9609 | ||||||||||||||||||||||
HPRD | 02026 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||