Version 5.4
Homo sapiens Gene: RNF123
Summary
InnateDB Gene IDBG-35201.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF123
Gene Name ring finger protein 123
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164068
Encoded Proteins
IDBP-35203
ring finger protein 123
IDBP-377548
ring finger protein 123
IDBP-377557
ring finger protein 123
IDBP-377561
ring finger protein 123
IDBP-377563
ring finger protein 123
IDBP-377565
ring finger protein 123
IDBP-377570
ring finger protein 123
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49689499-49721529
Strand Forward strand
Band p21.31
Transcripts
ENST00000327697 ENSP00000328287
ENST00000432042 ENSP00000392443
ENST00000457726 ENSP00000394369
ENST00000443204 ENSP00000390856
ENST00000454491 ENSP00000408490
ENST00000433785 ENSP00000416156
ENST00000444689 ENSP00000413794
ENST00000486102
ENST00000487805
ENST00000494005
ENST00000469978
ENST00000497099
ENST00000498376
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041528
View Gene Order
ENSBTAG00000011588
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.553723 Hs.741120
RefSeq NM_022064 XM_006713285
HUGO
OMIM
CCDS CCDS33758
HPRD 11499
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca