InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NAMPT

Summary

InnateDB Gene

IDBG-35259.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAMPT

Gene Name

nicotinamide phosphoribosyltransferase

Synonyms

1110035O14Rik; PBEF; PBEF1; VF; VISFATIN

Species

Homo sapiens

Ensembl Gene

ENSG00000105835

Encoded Proteins

IDBP-35261

nicotinamide phosphoribosyltransferase

IDBP-35263

nicotinamide phosphoribosyltransferase

IDBP-384944

nicotinamide phosphoribosyltransferase

IDBP-384947

nicotinamide phosphoribosyltransferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22377803

NAMPT secretion is enhanced by extracellular ATP in LPS-primed monocytes.

InnateDB Annotation from Orthologs

Summary

PMID 22377803

[Mus musculus] Nampt secretion is enhanced by extracellular ATP in LPS-primed monocytes. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:106248285-106286326

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000222553	ENSP00000222553
ENST00000354289	ENSP00000346242
ENST00000393618
ENST00000441045
ENST00000424768	ENSP00000390591
ENST00000417537	ENSP00000390896
ENST00000463871
ENST00000491027
ENST00000467730
ENST00000484527
ENST00000486949
ENST00000489358
ENST00000489732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0047280	nicotinamide phosphoribosyltransferase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006769	nicotinamide metabolic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0009435	NAD biosynthetic process
GO:0014070	response to organic cyclic compound
GO:0019674	NAD metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process