Version 5.4
Homo sapiens Gene: ST8SIA4
Summary
InnateDB Gene IDBG-35324.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST8SIA4
Gene Name ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Synonyms PST; PST1; SIAT8D; ST8SIA-IV
Species Homo sapiens
Ensembl Gene ENSG00000113532
Encoded Proteins
IDBP-35326
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
IDBP-483089
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
IDBP-475346
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). The encoded protein, which is a member of glycosyltransferase family 29, is a type II membrane protein that may be present in the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:100806935-100903266
Strand Reverse strand
Band q21.1
Transcripts
ENST00000231461 ENSP00000231461
ENST00000451528 ENSP00000428914
ENST00000507360
ENST00000523381 ENSP00000428826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0033691 sialic acid binding
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0006464 cellular protein modification process
GO:0006486 protein glycosylation
GO:0006491 N-glycan processing
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0009311 oligosaccharide metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000040710
View Gene Order
ENSBTAG00000021445
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_18266
Axon guidance pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.308628
RefSeq NM_005668 NM_175052
HUGO
OMIM
CCDS CCDS4091 CCDS47252
HPRD 03970
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca