InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB8A

Summary

InnateDB Gene

IDBG-35329.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB8A

Gene Name

RAB8A, member RAS oncogene family

Synonyms

MEL; RAB8

Species

Homo sapiens

Ensembl Gene

ENSG00000167461

Encoded Proteins

IDBP-35331

RAB8A, member RAS oncogene family

IDBP-762623

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25022365

[Mus musculus] Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.

Entrez Gene

Summary

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%%, 96%%, and 51%% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:16111629-16134234

Strand

Forward strand

Band

p13.11

Transcripts

ENST00000300935	ENSP00000300935
ENST00000587156
ENST00000589697
ENST00000586682	ENSP00000467501
ENST00000590899
ENST00000588105
ENST00000592971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	54 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0017137	Rab GTPase binding
GO:0019003	GDP binding
GO:0019901	protein kinase binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006904	vesicle docking involved in exocytosis
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007409	axonogenesis
GO:0015031	protein transport
GO:0032869	cellular response to insulin stimulus
GO:0032880	regulation of protein localization
GO:0042384	cilium assembly
GO:0048169	regulation of long-term neuronal synaptic plasticity
GO:0048210	Golgi vesicle fusion to target membrane
GO:0051223	regulation of protein transport
GO:0061024	membrane organization
GO:0072659	protein localization to plasma membrane

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005929	cilium
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030140	trans-Golgi network transport vesicle
GO:0030425	dendrite
GO:0030659	cytoplasmic vesicle membrane
GO:0030670	phagocytic vesicle membrane
GO:0031513	nonmotile primary cilium
GO:0036064	ciliary basal body
GO:0043025	neuronal cell body
GO:0045335	phagocytic vesicle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003037

View Gene Order

ENSBTAG00000038696

Not yet available

Pathways

NETPATH

REACTOME

REACT_160315

Regulation of PLK1 Activity at G2/M Transition pathway

REACT_147867

Translocation of GLUT4 to the plasma membrane pathway

REACT_115566

Cell Cycle pathway

REACT_2203

G2/M Transition pathway

REACT_152

Cell Cycle, Mitotic pathway

REACT_21391

Mitotic G2-G2/M phases pathway

REACT_11123

Membrane Trafficking pathway

KEGG

hsa04972

Pancreatic secretion pathway

INOH

PID NCI

Cross-References

SwissProt

P61006

TrEMBL

A0A024R7I3 B4DEK7

UniProt Splice Variant

Entrez Gene

4218

UniGene

RefSeq

NM_005370

HUGO

HGNC:7007

OMIM

165040

CCDS

CCDS12339

HPRD

IMGT

EMBL

AC008894 AF498943 AK293676 BC002977 BT007184 CH471106 CR536583 CR542274 S53268 X56741

GenPept

AAB19681 AAH02977 AAM21091 AAP35848 BAG57118 CAA40065 CAG38820 CAG47070 EAW84526 EAW84527

RNA Seq Atlas

4218