Version 5.4
Homo sapiens Gene: KLF2
Summary
InnateDB Gene IDBG-35485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLF2
Gene Name Kruppel-like factor 2 (lung)
Synonyms LKLF
Species Homo sapiens
Ensembl Gene ENSG00000127528
Encoded Proteins
IDBP-35487
Kruppel-like factor 2 (lung)
IDBP-763566
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16324817-16327874
Strand Forward strand
Band p13.11
Transcripts
ENST00000248071 ENSP00000248071
ENST00000592003 ENSP00000465035
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0032715 negative regulation of interleukin-6 production
GO:0034101 erythrocyte homeostasis
GO:0034616 response to laminar fluid shear stress
GO:0035264 multicellular organism growth
GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0040029 regulation of gene expression, epigenetic
GO:0043249 erythrocyte maturation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051247 positive regulation of protein metabolic process
GO:0060509 Type I pneumocyte differentiation
GO:0070301 cellular response to hydrogen peroxide
GO:0071347 cellular response to interleukin-1
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071409 cellular response to cycloheximide
GO:0071499 cellular response to laminar fluid shear stress
GO:1901653 cellular response to peptide
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000055148
View Gene Order
Cross-References
SwissProt
TrEMBL K7EJ60
UniProt Splice Variant
Entrez Gene 10365
UniGene Hs.107740 Hs.741757
RefSeq NM_016270
HUGO HGNC:6347
OMIM 602016
CCDS CCDS12343
HPRD 03602
IMGT
EMBL AC020917
GenPept
RNA Seq Atlas 10365

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca