InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSRP3

Summary

InnateDB Gene

IDBG-35519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSRP3

Gene Name

cysteine and glycine-rich protein 3 (cardiac LIM protein)

Synonyms

CLP; CMD1M; CMH12; CRP3; LMO4; MLP

Species

Homo sapiens

Ensembl Gene

ENSG00000129170

Encoded Proteins

IDBP-35521

cysteine and glycine-rich protein 3 (cardiac LIM protein)

IDBP-593248

cysteine and glycine-rich protein 3 (cardiac LIM protein)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5\' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:19182030-19210573

Strand

Reverse strand

Band

p15.1

Transcripts

ENST00000265968	ENSP00000265968
ENST00000533783	ENSP00000431813

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008307	structural constituent of muscle
GO:0031433	telethonin binding
GO:0042805	actinin binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0003300	cardiac muscle hypertrophy
GO:0006874	cellular calcium ion homeostasis
GO:0007519	skeletal muscle tissue development
GO:0033365	protein localization to organelle
GO:0035995	detection of muscle stretch
GO:0048738	cardiac muscle tissue development
GO:0055003	cardiac myofibril assembly
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005856	cytoskeleton
GO:0030018	Z disc

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030470

View Gene Order

ENSBTAG00000011869

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.83577

RefSeq

NM_003476 XM_006718339

HUGO

OMIM

CCDS

CCDS7848

HPRD

07525

IMGT

EMBL

GenPept

RNA Seq Atlas