Version 5.4
Homo sapiens Gene: WRB
Summary
InnateDB Gene IDBG-3557.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WRB
Gene Name tryptophan rich basic protein
Synonyms CHD5
Species Homo sapiens
Ensembl Gene ENSG00000182093
Encoded Proteins
IDBP-3559
tryptophan rich basic protein
IDBP-3561
tryptophan rich basic protein
IDBP-3563
tryptophan rich basic protein
IDBP-232304
tryptophan rich basic protein
IDBP-366496
tryptophan rich basic protein
IDBP-366499
tryptophan rich basic protein
IDBP-812098
tryptophan rich basic protein
IDBP-812099
tryptophan rich basic protein
IDBP-812091
tryptophan rich basic protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:39380244-39428528
Strand Forward strand
Band q22.2
Transcripts
ENST00000380713 ENSP00000370089
ENST00000333781 ENSP00000327716
ENST00000380708 ENSP00000370084
ENST00000398753 ENSP00000381737
ENST00000442773 ENSP00000409030
ENST00000415847 ENSP00000410228
ENST00000487869
ENST00000471468
ENST00000466787 ENSP00000485215
ENST00000490860
ENST00000478273 ENSP00000485087
ENST00000476914
ENST00000480690
ENST00000623703 ENSP00000485555
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0071816 tail-anchored membrane protein insertion into ER membrane
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023147
View Gene Order
ENSBTAG00000013629
Not yet available
Cross-References
SwissProt
TrEMBL C9JLV3
UniProt Splice Variant
Entrez Gene 7485
UniGene Hs.720889 Hs.741308
RefSeq NM_001146218 NM_004627 XM_005261059 XM_005261060
HUGO HGNC:12790
OMIM 602915
CCDS CCDS13664 CCDS54485
HPRD 04224
IMGT
EMBL AF064861 AF121781
GenPept
RNA Seq Atlas 7485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca