Version 5.4
Homo sapiens Gene: E2F8
Summary
InnateDB Gene IDBG-35571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F8
Gene Name E2F transcription factor 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000129173
Encoded Proteins
IDBP-35573
E2F transcription factor 8
IDBP-585610
E2F transcription factor 8
IDBP-597764
E2F transcription factor 8
IDBP-811267
E2F transcription factor 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:19224063-19241620
Strand Reverse strand
Band p15.1
Transcripts
ENST00000250024 ENSP00000250024
ENST00000527884 ENSP00000434199
ENST00000529188
ENST00000532666 ENSP00000437326
ENST00000620009 ENSP00000481103
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0002040 sprouting angiogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0008283 cell proliferation
GO:0032466 negative regulation of cytokinesis
GO:0032877 positive regulation of DNA endoreduplication
GO:0033301 cell cycle comprising mitosis without cytokinesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060707 trophoblast giant cell differentiation
GO:0060718 chorionic trophoblast cell differentiation
GO:0070365 hepatocyte differentiation
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000046179
View Gene Order
ENSBTAG00000017446
Not yet available
Cross-References
SwissProt A0AVK6
TrEMBL E9PMT9
UniProt Splice Variant
Entrez Gene 79733
UniGene Hs.523526 Hs.597313 Hs.627312
RefSeq NM_001256372 NM_001256371 NM_024680
HUGO HGNC:24727
OMIM 612047
CCDS CCDS7849
HPRD 10981
IMGT
EMBL AB231781 AC009652 AK026964 AK292688 BC028244 BC090877 BC108700 BC126400 BC126402 CH471064
GenPept AAH28244 AAH90877 AAI08701 AAI26401 AAI26403 BAB15605 BAE46901 BAF85377 EAW68354
RNA Seq Atlas 79733

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca