Homo sapiens Gene: F2RL3 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Gene | IDBG-35882.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | F2RL3 | ||||||||||||||||||||
Gene Name | coagulation factor II (thrombin) receptor-like 3 | ||||||||||||||||||||
Synonyms | PAR4 | ||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||
Ensembl Gene | ENSG00000127533 | ||||||||||||||||||||
Encoded Proteins |
coagulation factor II (thrombin) receptor-like 3
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Protein Structure | |||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||
Summary |
F2RL3 modulates inflammation in the lung where its activation stimulates IL6, IL8, and PTGER2 (prostaglandin E2) release from human respiratory epithelial cells.
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Entrez Gene | |||||||||||||||||||||
Summary |
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||
Genomic Location | Chromosome 19:16888860-16892606 | ||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||
Band | p13.11 | ||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||
NETPATH | |||||||||||||||||||||
REACTOME |
Thrombin signalling through proteinase activated receptors (PARs) pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Peptide ligand-binding receptors pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
Hemostasis pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||||
PID NCI |
PAR4-mediated thrombin signaling events
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Cross-References | |||||||||||||||||||||
SwissProt | Q96RI0 | ||||||||||||||||||||
TrEMBL | M0R0Y0 | ||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 9002 | ||||||||||||||||||||
UniGene | Hs.137574 | ||||||||||||||||||||
RefSeq | NM_003950 XM_005260139 | ||||||||||||||||||||
HUGO | HGNC:3540 | ||||||||||||||||||||
OMIM | 602779 | ||||||||||||||||||||
CCDS | CCDS12350 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AC008737 AF055917 AF080214 AF384819 AY431102 BC074782 | ||||||||||||||||||||
GenPept | AAC25699 AAC28860 AAH74782 AAK61908 AAR08487 | ||||||||||||||||||||
RNA Seq Atlas | 9002 | ||||||||||||||||||||