InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAD2L1

Summary

InnateDB Gene

IDBG-35919.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAD2L1

Gene Name

MAD2 mitotic arrest deficient-like 1 (yeast)

Synonyms

HSMAD2; MAD2

Species

Homo sapiens

Ensembl Gene

ENSG00000164109

Encoded Proteins

IDBP-35921

MAD2 mitotic arrest deficient-like 1 (yeast)

IDBP-35923

MAD2 mitotic arrest deficient-like 1 (yeast)

IDBP-479170

MAD2 mitotic arrest deficient-like 1 (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:120055608-120067074

Strand

Reverse strand

Band

q27

Transcripts

ENST00000296509	ENSP00000296509
ENST00000333047	ENSP00000332295
ENST00000512484
ENST00000504707	ENSP00000425702
ENST00000511295

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	93 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000070	mitotic sister chromatid segregation
GO:0000278	mitotic cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0042177	negative regulation of protein catabolic process
GO:0043066	negative regulation of apoptotic process
GO:0045930	negative regulation of mitotic cell cycle
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0060564	negative regulation of mitotic anaphase-promoting complex activity
GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm
GO:0072686	mitotic spindle