InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EFNA5

Summary

InnateDB Gene

IDBG-36100.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNA5

Gene Name

ephrin-A5

Synonyms

AF1; EFL5; EPLG7; GLC1M; LERK7; RAGS

Species

Homo sapiens

Ensembl Gene

ENSG00000184349

Encoded Proteins

IDBP-36104

ephrin-A5

IDBP-485329

ephrin-A5

IDBP-809107

ephrin-A5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:107376889-107670895

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000333274	ENSP00000328777
ENST00000510359
ENST00000509503	ENSP00000426989
ENST00000504941
ENST00000505499
ENST00000611503	ENSP00000484681

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0045499	chemorepellent activity
GO:0046875	ephrin receptor binding

Biological Process

GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0022407	regulation of cell-cell adhesion
GO:0031290	retinal ganglion cell axon guidance
GO:0032314	regulation of Rac GTPase activity
GO:0032319	regulation of Rho GTPase activity
GO:0032956	regulation of actin cytoskeleton organization
GO:0048013	ephrin receptor signaling pathway
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050919	negative chemotaxis
GO:0051893	regulation of focal adhesion assembly
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0070507	regulation of microtubule cytoskeleton organization