InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GNAI2

Summary

InnateDB Gene

IDBG-36105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNAI2

Gene Name

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Synonyms

GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1

Species

Homo sapiens

Ensembl Gene

ENSG00000114353

Encoded Proteins

IDBP-36107

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-36109

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-378032

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-378036

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-378037

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-378038

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

IDBP-378040

guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21255617

GNAI2 is regulated by TLR signalling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis. (Demonstrated in murine model)

PMID 22581266

Sustained activation of GNAI2 dampens TNF and IL6 production stimulated by TLR2/4 ligands. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21255617

[Mus musculus] Gnai2 is regulated by Tlr signaling and plays an anti-inflammatory role in endotoxema and polymicrobial sepsis.

PMID 22581266

[Mus musculus] Sustained activation of Gnai2 dampens Tnf and Il6 production stimulated by Tlr2/4 ligands.

Entrez Gene

Summary

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq, Oct 2009]
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50226292-50259355

Strand

Forward strand

Band

p21.31

Transcripts

ENST00000266027	ENSP00000266027
ENST00000313601	ENSP00000312999
ENST00000422163	ENSP00000406871
ENST00000446079	ENSP00000406065
ENST00000441156	ENSP00000394321
ENST00000440628	ENSP00000395736
ENST00000451956	ENSP00000406369
ENST00000491100
ENST00000480090
ENST00000490122
ENST00000468422
ENST00000492383

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 91 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	91 [view]
Protein-Protein	91 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding
GO:0046872	metal ion binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001973	adenosine receptor signaling pathway
GO:0006184	GTP catabolic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007214	gamma-aminobutyric acid signaling pathway
GO:0007268	synaptic transmission
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0030168	platelet activation
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0050805	negative regulation of synaptic transmission
GO:0051301	cell division
GO:0051924	regulation of calcium ion transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005834	heterotrimeric G-protein complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome