Version 5.4
Homo sapiens Gene: FER
Summary
InnateDB Gene IDBG-36195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FER
Gene Name fer (fps/fes related) tyrosine kinase
Synonyms FerT; Pe1Fe10; Pe1Fe13; Pe1Fe3; Pe1Fe6; PPP1R74; TYK3
Species Homo sapiens
Ensembl Gene ENSG00000151422
Encoded Proteins
IDBP-36199
fer (fps/fes related) tyrosine kinase
IDBP-374537
fer (fps/fes related) tyrosine kinase
IDBP-481061
fer (fps/fes related) tyrosine kinase
IDBP-808842
fer (fps/fes related) tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23355730
[Mus musculus] FER is an inhibitory kinase for neutrophil chemotaxis.
Entrez Gene
Summary Fer protein is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:108747822-109196841
Strand Forward strand
Band q21.3
Transcripts
ENST00000281092 ENSP00000281092
ENST00000438717 ENSP00000394297
ENST00000509035
ENST00000513676
ENST00000504143 ENSP00000421951
ENST00000502752
ENST00000505323
ENST00000513777
ENST00000618353 ENSP00000484767
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008092 cytoskeletal protein binding
GO:0008157 protein phosphatase 1 binding
GO:0008289 lipid binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017137 Rab GTPase binding
GO:0019901 protein kinase binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0001932 regulation of protein phosphorylation
GO:0006468 protein phosphorylation
GO:0006935 chemotaxis
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010591 regulation of lamellipodium assembly
GO:0010762 regulation of fibroblast migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030335 positive regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031532 actin cytoskeleton reorganization
GO:0032496 response to lipopolysaccharide
GO:0032869 cellular response to insulin stimulus
GO:0033007 negative regulation of mast cell activation involved in immune response
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034614 cellular response to reactive oxygen species
GO:0035426 extracellular matrix-cell signaling
GO:0035556 intracellular signal transduction
GO:0036006 cellular response to macrophage colony-stimulating factor stimulus
GO:0036119 response to platelet-derived growth factor stimulus
GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038109 Kit signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0046777 protein autophosphorylation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050904 diapedesis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070102 interleukin-6-mediated signaling pathway
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0030027 lamellipodium
GO:0030054 cell junction
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000127
View Gene Order
ENSBTAG00000003051
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
REACTOME
REACT_111040
Signaling by SCF-KIT pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04520
Adherens junction pathway
INOH
PID NCI
ptp1bpathway
Signaling events mediated by PTP1B
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
fcer1pathway
Fc-epsilon receptor I signaling in mast cells
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.107418 Hs.221472 Hs.610251 Hs.625304 Hs.712671 Hs.738119 Hs.738538
RefSeq NM_005246 XM_006714572 XM_006714573
HUGO
OMIM
CCDS CCDS4098
HPRD 01491
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca