InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: E2F4

Summary

InnateDB Gene

IDBG-36221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E2F4

Gene Name

E2F transcription factor 4, p107/p130-binding

Synonyms

E2F-4

Species

Homo sapiens

Ensembl Gene

ENSG00000205250

Encoded Proteins

IDBP-36223

E2F transcription factor 4, p107/p130-binding

IDBP-749220

IDBP-747478

IDBP-751212

IDBP-749767

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:67192169-67198918

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000379378	ENSP00000368686
ENST00000568485
ENST00000565849	ENSP00000454477
ENST00000566368
ENST00000567228
ENST00000565226	ENSP00000458706
ENST00000563238
ENST00000567007
ENST00000569573	ENSP00000457239
ENST00000568693
ENST00000564718
ENST00000568839	ENSP00000458082
ENST00000561904

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 483 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	485 [view]
Protein-Protein	77 [view]
Protein-DNA	405 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019904	protein domain specific binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006884	cell volume homeostasis
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0008015	blood circulation
GO:0008361	regulation of cell size
GO:0009887	organ morphogenesis
GO:0010467	gene expression
GO:0042127	regulation of cell proliferation
GO:0042384	cilium assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter