Homo sapiens Gene: MRPL34
Summary
InnateDB Gene IDBG-36369.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MRPL34
Gene Name mitochondrial ribosomal protein L34
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130312
Encoded Proteins
mitochondrial ribosomal protein L34
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17292609-17306843
Strand Forward strand
Band p13.11
Transcripts
ENST00000252602 ENSP00000252602
ENST00000600434 ENSP00000469581
ENST00000602206 ENSP00000471089
ENST00000594999 ENSP00000471820
ENST00000597996
ENST00000595444 ENSP00000472266
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005761 mitochondrial ribosome
GO:0005840 ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Organelle biogenesis and maintenance pathway
Mitochondrial translation pathway
Mitochondrial translation initiation pathway
Mitochondrial translation termination pathway
Mitochondrial translation elongation pathway
KEGG
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt Q9BQ48
TrEMBL A0A024R7J4 M0R093 M0R226
UniProt Splice Variant
Entrez Gene 64981
UniGene Hs.665551 Hs.701506
RefSeq NM_023937
HUGO HGNC:14488
OMIM 611840
CCDS CCDS12356
HPRD
IMGT
EMBL AB049652 AC010463 BC000071 BC021801 CH471106
GenPept AAH00071 AAH21801 BAB40857 EAW84590 EAW84591 EAW84592
RNA Seq Atlas 64981