Version 5.4
Homo sapiens Gene: TNFAIP1
Summary
InnateDB Gene IDBG-36399.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFAIP1
Gene Name tumor necrosis factor, alpha-induced protein 1 (endothelial)
Synonyms B12; B61; BTBD34; EDP1; hBACURD2
Species Homo sapiens
Ensembl Gene ENSG00000109079
Encoded Proteins
IDBP-36401
tumor necrosis factor, alpha-induced protein 1 (endothelial)
IDBP-601407
tumor necrosis factor, alpha-induced protein 1 (endothelial)
IDBP-759316
IDBP-759045
IDBP-761147
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28335602-28347009
Strand Forward strand
Band q11.2
Transcripts
ENST00000226225 ENSP00000226225
ENST00000544907 ENSP00000440749
ENST00000582302 ENSP00000464515
ENST00000583213
ENST00000577535 ENSP00000466301
ENST00000578158 ENSP00000464637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006260 DNA replication
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0009790 embryo development
GO:0016477 cell migration
GO:0016567 protein ubiquitination
GO:0035024 negative regulation of Rho protein signal transduction
GO:0043149 stress fiber assembly
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045740 positive regulation of DNA replication
GO:0051260 protein homooligomerization
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017615
View Gene Order
ENSBTAG00000008115
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.76090
RefSeq NM_021137
HUGO
OMIM
CCDS CCDS11227
HPRD 01856
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca